The usual dosage is 30 to 50 mg/kg/day, in equally divided doses. For more severe infections this dosage may be doubled but should not exceed 4 g per day. In the treatment of streptococcal infections of the upper respiratory tract (e.g., tonsillitis or pharyngitis), the therapeutic dosage of erythromycin should be administered for at least tenFor oral dosage form (extended-release tablets): For acute uncomplicated pyelonephritis: Adults—1000 milligrams (mg) once a day. Children—Use and dose must be determined by your doctor. For complicated urinary tract infections: Adults—1000 milligrams (mg) once a day. Children—Use and dose must be determined by your doctor.
Recent publications show that there is no clear difference between a single dose vs. a 4–7 day short course of antibiotics for lower UTI treatment, in terms of progression to pyelonephritis (very low-quality evidence) and preterm birth (moderate-quality evidence) .
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